4jb8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4jb8" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4jb8| PDB=4jb8 | SCENE= }}
 +
===Caspase-7 in Complex with DARPin C7_16===
 +
{{ABSTRACT_PUBMED_23868333}}
-
The entry 4jb8 is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
-
Authors: Fluetsch, A., Seeger, M.A., Gruetter, M.G.
+
==About this Structure==
 +
[[4jb8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JB8 OCA].
-
Description: Caspase-7 in Complex with DARPin C7_16
+
==Reference==
 +
<ref group="xtra">PMID:023868333</ref><references group="xtra"/><references/>
 +
[[Category: Caspase-7]]
 +
[[Category: Homo sapiens]]
 +
[[Category: Synthetic construct]]
 +
[[Category: Fluetsch, A.]]
 +
[[Category: Gruetter, M G.]]
 +
[[Category: Seeger, M A.]]
 +
[[Category: Complex structure]]
 +
[[Category: Hydrolase-de novo protein complex]]
 +
[[Category: Selected darpin c7_16]]

Revision as of 08:20, 21 August 2013

Template:STRUCTURE 4jb8

Contents

Caspase-7 in Complex with DARPin C7_16

Template:ABSTRACT PUBMED 23868333

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

About this Structure

4jb8 is a 3 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA.

Reference

  • Seeger MA, Zbinden R, Flutsch A, Gutte PG, Engeler S, Roschitzki-Voser H, Grutter MG. Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity. Protein Sci. 2013 Jul 19. doi: 10.1002/pro.2312. PMID:23868333 doi:10.1002/pro.2312

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4jb8"
Personal tools