4igh

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'''Unreleased structure'''
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{{STRUCTURE_4igh| PDB=4igh | SCENE= }}
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===High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog===
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{{ABSTRACT_PUBMED_23930152}}
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The entry 4igh is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
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Authors: Deng, X., Das, P., Fontoura, B.M.A., Phillips, M.A., De Brabander, J.K.
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==Function==
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[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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Description: High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog
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==About this Structure==
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[[4igh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGH OCA].
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==Reference==
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<ref group="xtra">PMID:023930152</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Brabander, J K.De.]]
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[[Category: Das, P.]]
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[[Category: Deng, X.]]
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[[Category: Fontoura, B M.A.]]
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[[Category: Phillips, M A.]]
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[[Category: Anti-viral]]
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[[Category: Dehydrogenase]]
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[[Category: Fmn]]
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[[Category: Membrane]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Quinoline-4-carboxylic acid]]
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[[Category: Redox]]

Revision as of 08:27, 21 August 2013

Template:STRUCTURE 4igh

Contents

High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog

Template:ABSTRACT PUBMED 23930152

Disease

[PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.[1]

Function

[PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

About this Structure

4igh is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Das P, Deng X, Zhang L, Roth MG, Fontoura BM, Phillips MA, De Brabander JK. SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity. ACS Med Chem Lett. 2013 Jun 13;4(6):517-521. PMID:23930152 doi:10.1021/ml300464h
  1. ↑ Ng SB, Buckingham KJ, Lee C, Bigham AW, Tabor HK, Dent KM, Huff CD, Shannon PT, Jabs EW, Nickerson DA, Shendure J, Bamshad MJ. Exome sequencing identifies the cause of a mendelian disorder. Nat Genet. 2010 Jan;42(1):30-5. doi: 10.1038/ng.499. Epub 2009 Nov 13. PMID:19915526 doi:10.1038/ng.499

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OCA

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