4j3b
From Proteopedia
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{{STRUCTURE_4j3b| PDB=4j3b | SCENE= }} | {{STRUCTURE_4j3b| PDB=4j3b | SCENE= }} | ||
===A naturally variable residue in the S1 subsite of M1-family aminopeptidases modulates catalytic properties and promotes functional specialization=== | ===A naturally variable residue in the S1 subsite of M1-family aminopeptidases modulates catalytic properties and promotes functional specialization=== | ||
| + | {{ABSTRACT_PUBMED_23897806}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4j3b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_fcb1/columbia Plasmodium falciparum fcb1/columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3B OCA]. | [[4j3b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_fcb1/columbia Plasmodium falciparum fcb1/columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3B OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Aminopeptidase|Aminopeptidase]] | ||
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:023897806</ref><references group="xtra"/><references/> |
[[Category: Plasmodium falciparum fcb1/columbia]] | [[Category: Plasmodium falciparum fcb1/columbia]] | ||
[[Category: Dalal, S.]] | [[Category: Dalal, S.]] | ||
Revision as of 08:27, 21 August 2013
Contents |
A naturally variable residue in the S1 subsite of M1-family aminopeptidases modulates catalytic properties and promotes functional specialization
Template:ABSTRACT PUBMED 23897806
Function
[AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.[1] [2]
About this Structure
4j3b is a 1 chain structure with sequence from Plasmodium falciparum fcb1/columbia. Full crystallographic information is available from OCA.
See Also
Reference
- Dalal S, Ragheb DR, Schubot FD, Klemba M. A naturally variable residue in the S1 subsite of M1-family aminopeptidases modulates catalytic properties and promotes functional specialization. J Biol Chem. 2013 Jul 29. PMID:23897806 doi:10.1074/jbc.M113.465625
- ↑ Allary M, Schrevel J, Florent I. Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase. Parasitology. 2002 Jul;125(Pt 1):1-10. PMID:12166515
- ↑ McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A. 2009 Feb 5. PMID:19196988
