4l5n
From Proteopedia
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{{STRUCTURE_4l5n| PDB=4l5n | SCENE= }} | {{STRUCTURE_4l5n| PDB=4l5n | SCENE= }} | ||
===Crystallographic Structure of HHV-1 Uracil-DNA Glycosylase complexed with the Bacillus phage PZA inhibitor protein p56=== | ===Crystallographic Structure of HHV-1 Uracil-DNA Glycosylase complexed with the Bacillus phage PZA inhibitor protein p56=== | ||
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==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
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[[Category: Bacillus phage pza]] | [[Category: Bacillus phage pza]] | ||
[[Category: Uracil-DNA glycosylase]] | [[Category: Uracil-DNA glycosylase]] | ||
Revision as of 08:27, 21 August 2013
Contents |
Crystallographic Structure of HHV-1 Uracil-DNA Glycosylase complexed with the Bacillus phage PZA inhibitor protein p56
Template:ABSTRACT PUBMED 23892286
Function
[UNG_HHV11] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.[1] [2]
About this Structure
4l5n is a 6 chain structure with sequence from Bacillus phage pza and Herpes simplex virus (type 1 / strain 17). Full crystallographic information is available from OCA.
Reference
- Cole AR, Ofer S, Ryzhenkova K, Baltulionis G, Hornyak P, Savva R. Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase. Nucleic Acids Res. 2013 Jul 26. PMID:23892286 doi:10.1093/nar/gkt633
- ↑ Savva R, Pearl LH. Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex. Nat Struct Biol. 1995 Sep;2(9):752-7. PMID:7552746
- ↑ Krusong K, Carpenter EP, Bellamy SR, Savva R, Baldwin GS. A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1. J Biol Chem. 2006 Feb 24;281(8):4983-92. Epub 2005 Nov 22. PMID:16306042 doi:http://dx.doi.org/10.1074/jbc.M509137200
