4bof

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'''Unreleased structure'''
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{{STRUCTURE_4bof| PDB=4bof | SCENE= }}
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===Crystal structure of arginine deiminase from group A streptococcus===
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{{ABSTRACT_PUBMED_23919999}}
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The entry 4bof is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ARCA_STRPY ARCA_STRPY]] Antitumor protein. Has a powerful and dose-dependent inhibitory effect on antigen, superantigen, or mitogen-stimulated human peripheral blood mononuclear cell (PBMC) proliferation. It may inhibit cell proliferation by arresting cell cycle and inducing apoptosis (By similarity).[HAMAP-Rule:MF_00242]
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Authors: Henningham, A., Ericsson, D.J., Langer, K., Casey, L., Jovcevski, B., Chhatwal, G.S., Aquilina, J.A., Batzloff, M.R., Kobe, B., Walker, M.J.
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==About this Structure==
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[[4bof]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOF OCA].
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Description: Crystal structure of arginine deiminase from group A streptococcus
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==Reference==
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<ref group="xtra">PMID:023919999</ref><references group="xtra"/><references/>
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[[Category: Arginine deiminase]]
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[[Category: Streptococcus pyogenes]]
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[[Category: Aquilina, J A.]]
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[[Category: Batzloff, M R.]]
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[[Category: Casey, L.]]
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[[Category: Chhatwal, G S.]]
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[[Category: Ericsson, D J.]]
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[[Category: Henningham, A.]]
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[[Category: Jovcevski, B.]]
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[[Category: Kobe, B.]]
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[[Category: Langer, K.]]
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[[Category: Walker, M J.]]
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[[Category: Hydrolase]]
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[[Category: Vaccine]]

Revision as of 08:29, 21 August 2013

Template:STRUCTURE 4bof

Contents

Crystal structure of arginine deiminase from group A streptococcus

Template:ABSTRACT PUBMED 23919999

Function

[ARCA_STRPY] Antitumor protein. Has a powerful and dose-dependent inhibitory effect on antigen, superantigen, or mitogen-stimulated human peripheral blood mononuclear cell (PBMC) proliferation. It may inhibit cell proliferation by arresting cell cycle and inducing apoptosis (By similarity).[HAMAP-Rule:MF_00242]

About this Structure

4bof is a 8 chain structure with sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.

Reference

  • Henningham A, Ericsson DJ, Langer K, Casey LW, Jovcevski B, Chhatwal GS, Aquilina JA, Batzloff MR, Kobe B, Walker MJ. Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. MBio. 2013 Aug 6;4(4). pii: e00509-13. doi: 10.1128/mBio.00509-13. PMID:23919999 doi:10.1128/mBio.00509-13

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OCA

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