4ldm

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'''Unreleased structure'''
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{{STRUCTURE_4ldm| PDB=4ldm | SCENE= }}
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===Crystal Structure of an RNA-free VP40 Octameric Ring===
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The entry 4ldm is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/VP40_EBOZM VP40_EBOZM]] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.<ref>PMID:15892969</ref> <ref>PMID:16719918</ref>
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Authors: Bornholdt, Z.A., Ableson, D.M., Saphire, E.O.
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==About this Structure==
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[[4ldm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDM OCA].
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Description: Crystal Structure of an RNA-free VP40 Octameric Ring
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Zaire ebolavirus]]
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[[Category: Ableson, D M.]]
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[[Category: Bornholdt, Z A.]]
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[[Category: Saphire, E O.]]
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[[Category: Ebolavirus matrix protein]]
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[[Category: Rna binding ring]]
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[[Category: Viral protein]]
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[[Category: Viral transcription regulation]]

Revision as of 08:37, 21 August 2013

Template:STRUCTURE 4ldm

Contents

Crystal Structure of an RNA-free VP40 Octameric Ring

Function

[VP40_EBOZM] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.[1] [2]

About this Structure

4ldm is a 1 chain structure with sequence from Zaire ebolavirus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Irie T, Licata JM, Harty RN. Functional characterization of Ebola virus L-domains using VSV recombinants. Virology. 2005 Jun 5;336(2):291-8. PMID:15892969 doi:10.1016/j.virol.2005.03.027
  2. ↑ Johnson RF, Bell P, Harty RN. Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology. Virol J. 2006 May 23;3:31. PMID:16719918 doi:10.1186/1743-422X-3-31

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