4lz2

From Proteopedia

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m (Protected "4lz2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4lz2| PDB=4lz2 | SCENE= }}
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===Crystal structure of the bromodomain of human BAZ2A===
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The entry 4lz2 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
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Authors: Tallant, C., Nunez-Alonso, G., Picaud, S., Filippakopoulos, P., Krojer, T., Bradley, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4lz2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LZ2 OCA].
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Description: Crystal structure of the bromodomain of human BAZ2A
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Bradley, A.]]
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[[Category: Delft, F von.]]
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[[Category: Edwards, A M.]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Knapp, S.]]
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[[Category: Krojer, T.]]
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[[Category: Nunez-Alonso, G.]]
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[[Category: Picaud, S.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tallant, C.]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Structural genomics consortium]]

Revision as of 08:38, 21 August 2013

Template:STRUCTURE 4lz2

Crystal structure of the bromodomain of human BAZ2A

Function

[BAZ2A_HUMAN] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).

About this Structure

4lz2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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