2ki5
From Proteopedia
(New page: 200px<br /><applet load="2ki5" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ki5, resolution 1.90Å" /> '''HERPES SIMPLEX TYPE-...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2ki5.gif|left|200px]]<br /><applet load="2ki5" size=" | + | [[Image:2ki5.gif|left|200px]]<br /><applet load="2ki5" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2ki5, resolution 1.90Å" /> | caption="2ki5, resolution 1.90Å" /> | ||
'''HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION'''<br /> | '''HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Treatment of herpes infections with nucleoside analogues requires as an | + | Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties. |
==About this Structure== | ==About this Structure== | ||
| - | 2KI5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with SO4 and AC2 as [http://en.wikipedia.org/wiki/ligands ligands]. This structure | + | 2KI5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=AC2:'>AC2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entry 1KI5. Active as [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KI5 OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 15: | ||
[[Category: Thymidine kinase]] | [[Category: Thymidine kinase]] | ||
[[Category: Batuwangala, T.]] | [[Category: Batuwangala, T.]] | ||
| - | [[Category: Bennett, M | + | [[Category: Bennett, M S.]] |
| - | [[Category: Champness, J | + | [[Category: Champness, J N.]] |
[[Category: Rutherford, T.]] | [[Category: Rutherford, T.]] | ||
| - | [[Category: Sanderson, M | + | [[Category: Sanderson, M R.]] |
| - | [[Category: Summers, W | + | [[Category: Summers, W C.]] |
[[Category: Sun, H.]] | [[Category: Sun, H.]] | ||
[[Category: Wien, F.]] | [[Category: Wien, F.]] | ||
| Line 28: | Line 28: | ||
[[Category: transferase (phosphotransferase) thymidine kinase; viridae; ds-dna enveloped viruses; herpesviridae; alphaherpesvirinae antiviral drug (aciclovir)]] | [[Category: transferase (phosphotransferase) thymidine kinase; viridae; ds-dna enveloped viruses; herpesviridae; alphaherpesvirinae antiviral drug (aciclovir)]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:06:56 2008'' |
Revision as of 16:07, 21 February 2008
|
HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION
Overview
Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties.
About this Structure
2KI5 is a Single protein structure of sequence from Human herpesvirus 4 with and as ligands. This structure supersedes the now removed PDB entry 1KI5. Active as Thymidine kinase, with EC number 2.7.1.21 Full crystallographic information is available from OCA.
Reference
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:9989588
Page seeded by OCA on Thu Feb 21 18:06:56 2008
Categories: Human herpesvirus 4 | Single protein | Thymidine kinase | Batuwangala, T. | Bennett, M S. | Champness, J N. | Rutherford, T. | Sanderson, M R. | Summers, W C. | Sun, H. | Wien, F. | Wright, G. | AC2 | SO4 | Transferase (phosphotransferase) thymid | Transferase (phosphotransferase) thymidine kinase; viridae; ds-dna enveloped viruses; herpesviridae; alphaherpesvirinae antiviral drug (aciclovir)
