Sandbox Mati

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Revision as of 20:00, 27 August 2013

proteopedia linkproteopedia linkBcl-Xl is a member of the Bcl-2 family . This family consists of pro-apoptotic and anti-apoptotic members. Bcl-Xl(in the image)

spinqualitylabelsall models Bcl-Xl and ABT737 from PDB-ID 2yxj Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

,an anti apoptotic protein, binds pro apoptotic proteins like BAK and BAD thus inhibiting program cell death. Many cancer cells overexpress at least one of the anti-apoptotic members of this family , thus escaping apoptosis . Therefore these proteins are important targets for the development of new anti-cancer drugs.

[2yxj]