3snf
From Proteopedia
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{{STRUCTURE_3snf| PDB=3snf | SCENE= }} | {{STRUCTURE_3snf| PDB=3snf | SCENE= }} | ||
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===Onconase, atomic resolution crystal structure=== | ===Onconase, atomic resolution crystal structure=== | ||
| + | {{ABSTRACT_PUBMED_21895975}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/RNP30_RANPI RNP30_RANPI]] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA. | ||
==About this Structure== | ==About this Structure== | ||
[[3snf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rana_pipiens Rana pipiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SNF OCA]. | [[3snf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rana_pipiens Rana pipiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SNF OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:021895975</ref><references group="xtra"/><references/> | ||
[[Category: Rana pipiens]] | [[Category: Rana pipiens]] | ||
[[Category: Acharya, K R.]] | [[Category: Acharya, K R.]] | ||
Revision as of 04:50, 28 August 2013
Contents |
Onconase, atomic resolution crystal structure
Template:ABSTRACT PUBMED 21895975
Function
[RNP30_RANPI] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.
About this Structure
3snf is a 1 chain structure with sequence from Rana pipiens. Full crystallographic information is available from OCA.
Reference
- Holloway DE, Singh UP, Shogen K, Acharya KR. Crystal structure of Onconase at 1.1 A resolution--insights into substrate binding and collective motion. FEBS J. 2011 Nov;278(21):4136-49. doi: 10.1111/j.1742-4658.2011.08320.x. Epub, 2011 Sep 28. PMID:21895975 doi:10.1111/j.1742-4658.2011.08320.x
