3tzb
From Proteopedia
(Difference between revisions)
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| - | [[Image:3tzb.png|left|200px]] | ||
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{{STRUCTURE_3tzb| PDB=3tzb | SCENE= }} | {{STRUCTURE_3tzb| PDB=3tzb | SCENE= }} | ||
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===Quinone Oxidoreductase (NQ02) bound to NSC13000=== | ===Quinone Oxidoreductase (NQ02) bound to NSC13000=== | ||
| + | {{ABSTRACT_PUBMED_22090421}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Quinone reductase|Quinone reductase]] | *[[Quinone reductase|Quinone reductase]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022090421</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Dunstan, M S.]] | [[Category: Dunstan, M S.]] | ||
Revision as of 05:04, 28 August 2013
Contents |
Quinone Oxidoreductase (NQ02) bound to NSC13000
Template:ABSTRACT PUBMED 22090421
Function
[NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.[1]
About this Structure
3tzb is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Nolan KA, Dunstan MS, Caraher MC, Scott KA, Leys D, Stratford IJ. In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF-kappaB signaling. Mol Cancer Ther. 2012 Jan;11(1):194-203. doi: 10.1158/1535-7163.MCT-11-0543. Epub, 2011 Nov 16. PMID:22090421 doi:10.1158/1535-7163.MCT-11-0543
- ↑ Calamini B, Santarsiero BD, Boutin JA, Mesecar AD. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J. 2008 Jul 1;413(1):81-91. PMID:18254726 doi:10.1042/BJ20071373
