2lq7

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[[Image:2lq7.jpg|left|200px]]
 
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{{STRUCTURE_2lq7| PDB=2lq7 | SCENE= }}
{{STRUCTURE_2lq7| PDB=2lq7 | SCENE= }}
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===E2 binding surface on Uba3 beta-grasp domain undergoes a conformational transition===
===E2 binding surface on Uba3 beta-grasp domain undergoes a conformational transition===
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{{ABSTRACT_PUBMED_22821745}}
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==Function==
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[[http://www.uniprot.org/uniprot/UBA3_HUMAN UBA3_HUMAN]] Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.<ref>PMID:10207026</ref> <ref>PMID:9694792</ref> <ref>PMID:12740388</ref>
==About this Structure==
==About this Structure==
[[2lq7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQ7 OCA].
[[2lq7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQ7 OCA].
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==See Also==
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*[[Ubiquitin activating enzyme|Ubiquitin activating enzyme]]
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==Reference==
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<ref group="xtra">PMID:022821745</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Elgin, E S.]]
[[Category: Elgin, E S.]]

Revision as of 05:12, 28 August 2013

Template:STRUCTURE 2lq7

Contents

E2 binding surface on Uba3 beta-grasp domain undergoes a conformational transition

Template:ABSTRACT PUBMED 22821745

Function

[UBA3_HUMAN] Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.[1] [2] [3]

About this Structure

2lq7 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

See Also

Reference

  • Elgin ES, Sokmen N, Peterson FC, Volkman BF, Dag C, Haas AL. E2-binding surface on Uba3 beta-grasp domain undergoes a conformational transition. Proteins. 2012 Oct;80(10):2482-7. doi: 10.1002/prot.24148. Epub 2012 Jul 31. PMID:22821745 doi:10.1002/prot.24148
  1. ↑ Gong L, Yeh ET. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem. 1999 Apr 23;274(17):12036-42. PMID:10207026
  2. ↑ Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, Kawashima S, Tanaka K, Kato S. A new NEDD8-ligating system for cullin-4A. Genes Dev. 1998 Aug 1;12(15):2263-8. PMID:9694792
  3. ↑ Bohnsack RN, Haas AL. Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. J Biol Chem. 2003 Jul 18;278(29):26823-30. Epub 2003 May 10. PMID:12740388 doi:10.1074/jbc.M303177200

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