2mcm
From Proteopedia
(New page: 200px<br /><applet load="2mcm" size="450" color="white" frame="true" align="right" spinBox="true" caption="2mcm, resolution 1.5Å" /> '''MACROMOMYCIN'''<br />...) |
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| - | [[Image:2mcm.jpg|left|200px]]<br /><applet load="2mcm" size=" | + | [[Image:2mcm.jpg|left|200px]]<br /><applet load="2mcm" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2mcm, resolution 1.5Å" /> | caption="2mcm, resolution 1.5Å" /> | ||
'''MACROMOMYCIN'''<br /> | '''MACROMOMYCIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of macromomycin, the apoprotein of the antitumor | + | The crystal structure of macromomycin, the apoprotein of the antitumor antibiotic auromomycin, has been determined and refined at 1.6-A resolution. The overall structure is composed of a flattened seven-stranded antiparallel beta-barrel and two antiparallel beta-sheet ribbons. The barrel and the ribbons define a deep cleft that is the chromophore binding site. The cleft is very accessible and in this structure is occupied by two 2-methyl-2,4-pentanediol and two water molecules. The overall shape of the binding site is similar to that of the analogue actinoxanthin. Highly specific side chains that are not conserved between different analogues extend into the binding site and may be important to the chromophore binding specificity. |
==About this Structure== | ==About this Structure== | ||
| - | 2MCM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_macromomyceticus Streptomyces macromomyceticus] with CA, MRD and MPD as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2MCM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_macromomyceticus Streptomyces macromomyceticus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=MRD:'>MRD</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: apoprotein]] | [[Category: apoprotein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:07:46 2008'' |
Revision as of 16:07, 21 February 2008
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MACROMOMYCIN
Overview
The crystal structure of macromomycin, the apoprotein of the antitumor antibiotic auromomycin, has been determined and refined at 1.6-A resolution. The overall structure is composed of a flattened seven-stranded antiparallel beta-barrel and two antiparallel beta-sheet ribbons. The barrel and the ribbons define a deep cleft that is the chromophore binding site. The cleft is very accessible and in this structure is occupied by two 2-methyl-2,4-pentanediol and two water molecules. The overall shape of the binding site is similar to that of the analogue actinoxanthin. Highly specific side chains that are not conserved between different analogues extend into the binding site and may be important to the chromophore binding specificity.
About this Structure
2MCM is a Single protein structure of sequence from Streptomyces macromomyceticus with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure analysis of auromomycin apoprotein (macromomycin) shows importance of protein side chains to chromophore binding selectivity., Van Roey P, Beerman TA, Proc Natl Acad Sci U S A. 1989 Sep;86(17):6587-91. PMID:2771945
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