3v0p

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[[Image:3v0p.jpg|left|200px]]
 
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{{STRUCTURE_3v0p| PDB=3v0p | SCENE= }}
{{STRUCTURE_3v0p| PDB=3v0p | SCENE= }}
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===Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (4GW) and H-antigen acceptor===
===Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (4GW) and H-antigen acceptor===
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{{ABSTRACT_PUBMED_23836908}}
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==Function==
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[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
==About this Structure==
==About this Structure==
[[3v0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_caccae Bacteroides caccae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0P OCA].
[[3v0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_caccae Bacteroides caccae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0P OCA].
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==Reference==
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<ref group="xtra">PMID:023836908</ref><references group="xtra"/><references/>
[[Category: Bacteroides caccae]]
[[Category: Bacteroides caccae]]
[[Category: Jorgensen, R.]]
[[Category: Jorgensen, R.]]

Revision as of 05:32, 28 August 2013

Template:STRUCTURE 3v0p

Contents

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (4GW) and H-antigen acceptor

Template:ABSTRACT PUBMED 23836908

Function

[BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.

About this Structure

3v0p is a 2 chain structure with sequence from Bacteroides caccae. Full crystallographic information is available from OCA.

Reference

  • Jorgensen R, Pesnot T, Lee HJ, Palcic MM, Wagner GK. Base-modified donor analogues reveal novel dynamic features of a glycosyltransferase. J Biol Chem. 2013 Jul 8. PMID:23836908 doi:10.1074/jbc.M113.465963

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