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4gku
From Proteopedia
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| - | [[Image:4gku.jpg|left|200px]] | ||
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{{STRUCTURE_4gku| PDB=4gku | SCENE= }} | {{STRUCTURE_4gku| PDB=4gku | SCENE= }} | ||
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===Crystal structure of beta lactamase in PET-15B=== | ===Crystal structure of beta lactamase in PET-15B=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors. | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4gku]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GKU OCA]. | + | [[4gku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GKU OCA]. |
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| + | ==See Also== | ||
| + | *[[Beta-lactamase|Beta-lactamase]] | ||
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
| + | [[Category: Escherichia coli]] | ||
[[Category: Cao, C.]] | [[Category: Cao, C.]] | ||
[[Category: Zhang, Y.]] | [[Category: Zhang, Y.]] | ||
[[Category: Beta lactamase]] | [[Category: Beta lactamase]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 05:33, 28 August 2013
Contents |
Crystal structure of beta lactamase in PET-15B
Function
[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
About this Structure
4gku is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
