2msp
From Proteopedia
(New page: 200px<br /><applet load="2msp" size="450" color="white" frame="true" align="right" spinBox="true" caption="2msp, resolution 3.3Å" /> '''MAJOR SPERM PROTEIN, ...) |
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| - | [[Image:2msp.gif|left|200px]]<br /><applet load="2msp" size=" | + | [[Image:2msp.gif|left|200px]]<br /><applet load="2msp" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2msp, resolution 3.3Å" /> | caption="2msp, resolution 3.3Å" /> | ||
'''MAJOR SPERM PROTEIN, BETA ISOFORM, ENGINEERED C59S/T90C MUTANT, PUTATIVE SUBFILAMENT STRUCTURE, PH 8.5'''<br /> | '''MAJOR SPERM PROTEIN, BETA ISOFORM, ENGINEERED C59S/T90C MUTANT, PUTATIVE SUBFILAMENT STRUCTURE, PH 8.5'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Cell locomotion in amoeboid nematode sperm is generated by the vectorial | + | Cell locomotion in amoeboid nematode sperm is generated by the vectorial assembly and bundling of filaments of the major sperm protein (MSP). MSP filaments are constructed from two helical subfilaments and here we describe the structure of putative MSP subfilament helices determined by X-ray crystallography at 3.3 A resolution. In addition to establishing the interfaces involved in polymerization, this structural model shows that the MSP helices are constructed from dimers and have no overall polarity, suggesting that it is unlikely that molecular motors play a direct role in the generation of protrusive force in these amoeboid cells. |
==About this Structure== | ==About this Structure== | ||
| - | 2MSP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http:// | + | 2MSP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MSP OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Ascaris suum]] | [[Category: Ascaris suum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bullock, T | + | [[Category: Bullock, T L.]] |
| - | [[Category: Mccoy, A | + | [[Category: Mccoy, A J.]] |
[[Category: Stewart, M.]] | [[Category: Stewart, M.]] | ||
[[Category: cytoskeletal protein]] | [[Category: cytoskeletal protein]] | ||
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[[Category: nematode sperm cell motility protein]] | [[Category: nematode sperm cell motility protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:07:57 2008'' |
Revision as of 16:08, 21 February 2008
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MAJOR SPERM PROTEIN, BETA ISOFORM, ENGINEERED C59S/T90C MUTANT, PUTATIVE SUBFILAMENT STRUCTURE, PH 8.5
Overview
Cell locomotion in amoeboid nematode sperm is generated by the vectorial assembly and bundling of filaments of the major sperm protein (MSP). MSP filaments are constructed from two helical subfilaments and here we describe the structure of putative MSP subfilament helices determined by X-ray crystallography at 3.3 A resolution. In addition to establishing the interfaces involved in polymerization, this structural model shows that the MSP helices are constructed from dimers and have no overall polarity, suggesting that it is unlikely that molecular motors play a direct role in the generation of protrusive force in these amoeboid cells.
About this Structure
2MSP is a Single protein structure of sequence from Ascaris suum. Full crystallographic information is available from OCA.
Reference
Structural basis for amoeboid motility in nematode sperm., Bullock TL, McCoy AJ, Kent HM, Roberts TM, Stewart M, Nat Struct Biol. 1998 Mar;5(3):184-9. PMID:9501910
Page seeded by OCA on Thu Feb 21 18:07:57 2008
