4i91

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{{STRUCTURE_4i91| PDB=4i91 | SCENE= }}
{{STRUCTURE_4i91| PDB=4i91 | SCENE= }}
===Crystal Structure of Cytochrome P450 2B6 (Y226H/K262R) in complex with alpha-Pinene.===
===Crystal Structure of Cytochrome P450 2B6 (Y226H/K262R) in complex with alpha-Pinene.===
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{{ABSTRACT_PUBMED_23786449}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
[[4i91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I91 OCA].
[[4i91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I91 OCA].
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==See Also==
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*[[Cytochrome P450|Cytochrome P450]]
==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:023786449</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Halpert, J R.]]
[[Category: Halpert, J R.]]

Revision as of 05:56, 28 August 2013

Template:STRUCTURE 4i91

Contents

Crystal Structure of Cytochrome P450 2B6 (Y226H/K262R) in complex with alpha-Pinene.

Template:ABSTRACT PUBMED 23786449

Function

[CP2B6_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.[1]

About this Structure

4i91 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Wilderman PR, Shah MB, Jang HH, Stout CD, Halpert JR. Structural and Thermodynamic Basis of (+)-alpha-Pinene Binding to Human Cytochrome P450 2B6. J Am Chem Soc. 2013 Jul 17;135(28):10433-40. doi: 10.1021/ja403042k. Epub 2013, Jul 3. PMID:23786449 doi:10.1021/ja403042k
  1. ↑ Miyazawa M, Shindo M, Shimada T. Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. Xenobiotica. 2001 Oct;31(10):713-23. PMID:11695850 doi:10.1080/00498250110065595

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