4lh2

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'''Unreleased structure'''
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{{STRUCTURE_4lh2| PDB=4lh2 | SCENE= }}
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===Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with succinate===
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{{ABSTRACT_PUBMED_23928095}}
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The entry 4lh2 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AL4A1_MOUSE AL4A1_MOUSE]] Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity).
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Authors: Pemberton, T.A., Tanner, J.J.
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==About this Structure==
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[[4lh2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LH2 OCA].
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Description: Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with succinate
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==Reference==
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<ref group="xtra">PMID:023928095</ref><references group="xtra"/><references/>
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[[Category: 1-pyrroline-5-carboxylate dehydrogenase]]
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[[Category: Mus musculus]]
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[[Category: Pemberton, T A.]]
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[[Category: Tanner, J J.]]
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[[Category: Oxidoreductase]]
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[[Category: Proline catabolism]]
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[[Category: Rossmann fold]]
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[[Category: Substrate recognition]]

Revision as of 07:27, 28 August 2013

Template:STRUCTURE 4lh2

Contents

Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with succinate

Template:ABSTRACT PUBMED 23928095

Function

[AL4A1_MOUSE] Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity).

About this Structure

4lh2 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Pemberton TA, Tanner JJ. Structural basis of substrate selectivity of Delta-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): Semialdehyde chain length. Arch Biochem Biophys. 2013 Aug 6. pii: S0003-9861(13)00231-2. doi:, 10.1016/j.abb.2013.07.024. PMID:23928095 doi:10.1016/j.abb.2013.07.024

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OCA

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