3gmd
From Proteopedia
(Difference between revisions)
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| - | [[Image:3gmd.png|left|200px]] | ||
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{{STRUCTURE_3gmd| PDB=3gmd | SCENE= }} | {{STRUCTURE_3gmd| PDB=3gmd | SCENE= }} | ||
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===Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I=== | ===Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I=== | ||
| + | {{ABSTRACT_PUBMED_22901389}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | ||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]] | *[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022901389</ref><references group="xtra"/><references/> | ||
[[Category: 11-beta-hydroxysteroid dehydrogenase]] | [[Category: 11-beta-hydroxysteroid dehydrogenase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
Revision as of 08:57, 4 September 2013
Contents |
Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I
Template:ABSTRACT PUBMED 22901389
Function
[DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
About this Structure
3gmd is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
See Also
Reference
- Valeur E, Christmann-Franck S, Lepifre F, Carniato D, Cravo D, Charon C, Bozec S, Musil D, Hillertz P, Doare L, Schmidlin F, Lecomte M, Schultz M, Roche D. Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5909-14. doi:, 10.1016/j.bmcl.2012.07.070. Epub 2012 Jul 31. PMID:22901389 doi:10.1016/j.bmcl.2012.07.070
Categories: 11-beta-hydroxysteroid dehydrogenase | Mus musculus | Christmann-Franck, S. | Hillertz, P. | Lepifre, F. | Musil, D. | Roche, D. | Valeur, E. | Alpha/beta | Endoplasmic reticulum | Glycoprotein | Lipid metabolism | Membrane | Nadp | Oxidoreductase | Oxidoreductase-oxidoreductase inhibitor complex | Signal-anchor | Steroid metabolism | Transmembrane
