4juo

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{{STRUCTURE_4juo| PDB=4juo | SCENE= }}
{{STRUCTURE_4juo| PDB=4juo | SCENE= }}
===A low-resolution three-gate structure of topoisomerase IV from Streptococcus pneumoniae in space group H32===
===A low-resolution three-gate structure of topoisomerase IV from Streptococcus pneumoniae in space group H32===
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{{ABSTRACT_PUBMED_23965305}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:023965305</ref><references group="xtra"/><references/>
[[Category: Gekko coi]]
[[Category: Gekko coi]]
[[Category: Streptococcus pneumoniae tigr4]]
[[Category: Streptococcus pneumoniae tigr4]]

Revision as of 09:12, 4 September 2013

Template:STRUCTURE 4juo

Contents

A low-resolution three-gate structure of topoisomerase IV from Streptococcus pneumoniae in space group H32

Template:ABSTRACT PUBMED 23965305

Function

[PARC_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.[1] [2] [PARE_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.[3] [4]

About this Structure

4juo is a 6 chain structure with sequence from Gekko coi and Streptococcus pneumoniae tigr4. Full crystallographic information is available from OCA.

Reference

  • Laponogov I, Veselkov DA, Crevel IM, Pan XS, Fisher LM, Sanderson MR. Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport. Nucleic Acids Res. 2013 Aug 21. PMID:23965305 doi:10.1093/nar/gkt749
  1. Laponogov I, Veselkov DA, Sohi MK, Pan XS, Achari A, Yang C, Ferrara JD, Fisher LM, Sanderson MR. Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target. PLoS ONE. 2007 Mar 21;2(3):e301. PMID:17375187 doi:10.1371/journal.pone.0000301
  2. Laponogov I, Pan XS, Veselkov DA, McAuley KE, Fisher LM, Sanderson MR. Structural basis of gate-DNA breakage and resealing by type II topoisomerases. PLoS One. 2010 Jun 28;5(6):e11338. PMID:20596531 doi:10.1371/journal.pone.0011338
  3. Laponogov I, Veselkov DA, Sohi MK, Pan XS, Achari A, Yang C, Ferrara JD, Fisher LM, Sanderson MR. Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target. PLoS ONE. 2007 Mar 21;2(3):e301. PMID:17375187 doi:10.1371/journal.pone.0000301
  4. Laponogov I, Pan XS, Veselkov DA, McAuley KE, Fisher LM, Sanderson MR. Structural basis of gate-DNA breakage and resealing by type II topoisomerases. PLoS One. 2010 Jun 28;5(6):e11338. PMID:20596531 doi:10.1371/journal.pone.0011338

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