2nsn
From Proteopedia
(New page: 200px<br /> <applet load="2nsn" size="450" color="white" frame="true" align="right" spinBox="true" caption="2nsn, resolution 2.000Å" /> '''Crystal structure ...) |
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| - | [[Image:2nsn.gif|left|200px]]<br /> | + | [[Image:2nsn.gif|left|200px]]<br /><applet load="2nsn" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2nsn, resolution 2.000Å" /> | caption="2nsn, resolution 2.000Å" /> | ||
'''Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1'''<br /> | '''Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Nod-like receptors (NLRs), Nod1 and Nod2 are cytosolic detectors of | + | Nod-like receptors (NLRs), Nod1 and Nod2 are cytosolic detectors of pathogen-associated molecular patterns (PAMPs). Nod1 is a three-domain protein, consisting of a caspase activation and recruitment domain (CARD), a nucleotide-binding oligomerization domain (NOD), and a leucine-rich repeat domain (LRR). The binding of PAMPs to the LRR results in the activation of signaling through homophilic CARD-CARD interactions. Several CARD structures have been determined, including a recent NMR structure of Nod1 CARD. In contrast to the reported NMR structure, the crystal structure reported here is a dimer, where the sixth helix is swapped between two monomers. While the overall structure is very similar to the known CARD structures, this is the first report of a homodimeric CARD structure. The ability of the CARD to exist in monomeric and dimeric forms suggests another level of regulation in the activation of NLR proteins. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2NSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 2NSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Coussens, N | + | [[Category: Coussens, N P.]] |
[[Category: Ramaswamy, S.]] | [[Category: Ramaswamy, S.]] | ||
[[Category: six helix greek key motif]] | [[Category: six helix greek key motif]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:10:34 2008'' |
Revision as of 16:10, 21 February 2008
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Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1
Contents |
Overview
Nod-like receptors (NLRs), Nod1 and Nod2 are cytosolic detectors of pathogen-associated molecular patterns (PAMPs). Nod1 is a three-domain protein, consisting of a caspase activation and recruitment domain (CARD), a nucleotide-binding oligomerization domain (NOD), and a leucine-rich repeat domain (LRR). The binding of PAMPs to the LRR results in the activation of signaling through homophilic CARD-CARD interactions. Several CARD structures have been determined, including a recent NMR structure of Nod1 CARD. In contrast to the reported NMR structure, the crystal structure reported here is a dimer, where the sixth helix is swapped between two monomers. While the overall structure is very similar to the known CARD structures, this is the first report of a homodimeric CARD structure. The ability of the CARD to exist in monomeric and dimeric forms suggests another level of regulation in the activation of NLR proteins.
Disease
Known disease associated with this structure: Hydatidiform mole OMIM:[609661]
About this Structure
2NSN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the Nod1 caspase activation and recruitment domain., Coussens NP, Mowers JC, McDonald C, Nunez G, Ramaswamy S, Biochem Biophys Res Commun. 2007 Feb 2;353(1):1-5. Epub 2006 Dec 6. PMID:17173864
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