1w29

From Proteopedia

Revision as of 14:17, 30 October 2007

LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) BUTANE 1-PHOSPHATE

Overview

The enzymes involved in the biosynthesis of riboflavin represent, attractive targets for the development of drugs against bacterial, pathogens, because the inhibitors of these enzymes are not likely to, interfere with enzymes of the mammalian metabolism. Lumazine synthase, catalyzes the penultimate step in the riboflavin biosynthesis pathway. A, number of substituted purinetrione compounds represent a new class of, highly specific inhibitors of lumazine synthase from Mycobacterium, tuberculosis. To develop potent antibiotics for the treatment of, tuberculosis, we have determined the structure of lumazine synthase from, M. tuberculosis in complex with two purinetrione inhibitors and have, studied binding via isothermal titration calorimetry. The structures were, determined by molecular ... [(full description)]

About this Structure

1W29 is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with K, TS1, TS0, D1D and ACY as [ligands]. Active as [Riboflavin synthase], with EC number [2.5.1.9]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors., Morgunova E, Meining W, Illarionov B, Haase I, Jin G, Bacher A, Cushman M, Fischer M, Ladenstein R, Biochemistry. 2005 Mar 1;44(8):2746-58. PMID:15723519

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