4irs

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'''Unreleased structure'''
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{{STRUCTURE_4irs| PDB=4irs | SCENE= }}
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===Structure of the mouse CD1d-PyrC-alpha-GalCer-iNKT TCR complex===
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{{ABSTRACT_PUBMED_23960235}}
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The entry 4irs is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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Authors: Nemcovic, M., Zajonc, D.M.
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==About this Structure==
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[[4irs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IRS OCA].
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Description: Structure of the mouse CD1d-PyrC-alpha-GalCer-iNKT TCR complex
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==Reference==
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<ref group="xtra">PMID:023960235</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Nemcovic, M.]]
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[[Category: Zajonc, D M.]]
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[[Category: Antigen presentation]]
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[[Category: Glycolipid]]
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[[Category: Immune system]]
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[[Category: Nkt cell]]

Revision as of 10:47, 4 September 2013

Template:STRUCTURE 4irs

Contents

Structure of the mouse CD1d-PyrC-alpha-GalCer-iNKT TCR complex

Template:ABSTRACT PUBMED 23960235

Function

[CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.[1] [2] [3] [B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

About this Structure

4irs is a 4 chain structure with sequence from [1] and Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Aspeslagh S, Nemcovic M, Pauwels N, Venken K, Wang J, Van Calenbergh S, Zajonc DM, Elewaut D. Enhanced TCR Footprint by a Novel Glycolipid Increases NKT-Dependent Tumor Protection. J Immunol. 2013 Aug 19. PMID:23960235 doi:10.4049/jimmunol.1203134
  1. ↑ Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec;15(6):897-908. PMID:11754812
  2. ↑ Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439 doi:10.1084/jem.20051625
  3. ↑ Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091 doi:10.1038/ni1224

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