4iqu

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'''Unreleased structure'''
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{{STRUCTURE_4iqu| PDB=4iqu | SCENE= }}
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===Tdt core in complex with inhibitor (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid===
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{{ABSTRACT_PUBMED_23968551}}
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The entry 4iqu is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE]] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
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Authors: Gouge, J., Delarue, M.
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==About this Structure==
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[[4iqu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQU OCA].
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Description:
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==Reference==
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<ref group="xtra">PMID:023968551</ref><references group="xtra"/><references/>
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[[Category: DNA nucleotidylexotransferase]]
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[[Category: Mus musculus]]
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[[Category: Delarue, M.]]
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[[Category: Gouge, J.]]
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[[Category: Terminal transferase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 10:48, 4 September 2013

Template:STRUCTURE 4iqu

Contents

Tdt core in complex with inhibitor (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid

Template:ABSTRACT PUBMED 23968551

Function

[TDT_MOUSE] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

About this Structure

4iqu is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Costi R, Cuzzucoli Crucitti G, Pescatori L, Messore A, Scipione L, Tortorella S, Amoroso A, Crespan E, Campiglia P, Maresca B, Novellino E, Gouge J, Delarue MH, Maga G, Di Santo R. New Nucleotide-Competitive Non-Nucleoside Inhibitors of Terminal Deoxynucleotidyl Transferase: Discovery, Characterization and Crystal Structure in Complex with the Target. J Med Chem. 2013 Aug 22. PMID:23968551 doi:10.1021/jm4010187

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OCA

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