4b8e

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'''Unreleased structure'''
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{{STRUCTURE_4b8e| PDB=4b8e | SCENE= }}
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===PRY-SPRY domain of Trim25===
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The entry 4b8e is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TRI25_MOUSE TRI25_MOUSE]] Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs (By similarity).
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Authors: Kershaw, N.J., D'Cruz, A.A., Nicola, N.A., Nicholson, S.E., Babon, J.J.
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==About this Structure==
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[[4b8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8E OCA].
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Description: PRY-SPRY domain of Trim25
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[[Category: Mus musculus]]
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[[Category: Babon, J J.]]
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[[Category: Cruz, A A.D.]]
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[[Category: Kershaw, N J.]]
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[[Category: Nicholson, S E.]]
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[[Category: Nicola, N A.]]
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[[Category: Ligase]]

Revision as of 10:53, 4 September 2013

Template:STRUCTURE 4b8e

PRY-SPRY domain of Trim25

Function

[TRI25_MOUSE] Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs (By similarity).

About this Structure

4b8e is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

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OCA

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