4gwr

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'''Unreleased structure'''
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{{STRUCTURE_4gwr| PDB=4gwr | SCENE= }}
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===Crystal Structure of the second catalytic domain of protein disulfide isomerase P5===
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The entry 4gwr is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PDIA6_HUMAN PDIA6_HUMAN]] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.<ref>PMID:15466936</ref> <ref>PMID:12204115</ref>
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Authors: Vinaik, R., Kozlov, G., Gehring, K.
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==About this Structure==
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[[4gwr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWR OCA].
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Description: Crystal Structure of the second catalytic domain of protein disulfide isomerase P5
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Protein disulfide-isomerase]]
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[[Category: Gehring, K.]]
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[[Category: Kozlov, G.]]
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[[Category: Vinaik, R.]]
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[[Category: Bip]]
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[[Category: Disulfide isomerase]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Isomerase]]
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[[Category: Thioredoxin-like fold]]

Revision as of 10:57, 4 September 2013

Template:STRUCTURE 4gwr

Contents

Crystal Structure of the second catalytic domain of protein disulfide isomerase P5

Function

[PDIA6_HUMAN] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.[1] [2]

About this Structure

4gwr is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Jordan PA, Stevens JM, Hubbard GP, Barrett NE, Sage T, Authi KS, Gibbins JM. A role for the thiol isomerase protein ERP5 in platelet function. Blood. 2005 Feb 15;105(4):1500-7. Epub 2004 Oct 5. PMID:15466936 doi:10.1182/blood-2004-02-0608
  2. ↑ Kikuchi M, Doi E, Tsujimoto I, Horibe T, Tsujimoto Y. Functional analysis of human P5, a protein disulfide isomerase homologue. J Biochem. 2002 Sep;132(3):451-5. PMID:12204115

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