4m49

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m (Protected "4m49" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4m49| PDB=4m49 | SCENE= }}
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===Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18===
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The entry 4m49 is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
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Authors: Eigenbrot, C., Ultsch, M.
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==About this Structure==
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[[4m49]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA].
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Description: Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: L-lactate dehydrogenase]]
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[[Category: Eigenbrot, C.]]
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[[Category: Ultsch, M.]]
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[[Category: Dehydrogenase/reductase]]
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[[Category: Nicotinamide adenine dinucleotide nadh]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 11:02, 4 September 2013

Template:STRUCTURE 4m49

Contents

Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18

Disease

[LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.[1]

About this Structure

4m49 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Maekawa M, Sudo K, Kanno T, Li SS. Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency. Biochem Biophys Res Commun. 1990 Apr 30;168(2):677-82. PMID:2334430

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