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4mak

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4mak| PDB=4mak | SCENE= }}
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===Crystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coli===
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The entry 4mak is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CAS2_ECOLI CAS2_ECOLI]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).<ref>PMID:21255106</ref>
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Authors: Nocek, B., Skarina, T., Brown, G., Yakunin, A., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
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==About this Structure==
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[[4mak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr._mg1655 Escherichia coli str. k-12 substr. mg1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAK OCA].
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Description: Crystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coli
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Escherichia coli str. k-12 substr. mg1655]]
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[[Category: Brown, G.]]
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[[Category: Joachimiak, A.]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Nocek, B.]]
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[[Category: Skarina, T.]]
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[[Category: Yakunin, A.]]
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[[Category: Cas2]]
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[[Category: Crispr]]
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[[Category: Hydrolase]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]

Revision as of 11:02, 4 September 2013

Template:STRUCTURE 4mak

Contents

Crystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coli

Function

[CAS2_ECOLI] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).[1]

About this Structure

4mak is a 2 chain structure with sequence from Escherichia coli str. k-12 substr. mg1655. Full crystallographic information is available from OCA.

Reference

  1. ↑ Perez-Rodriguez R, Haitjema C, Huang Q, Nam KH, Bernardis S, Ke A, DeLisa MP. Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli. Mol Microbiol. 2011 Feb;79(3):584-99. doi: 10.1111/j.1365-2958.2010.07482.x. Epub, 2010 Dec 13. PMID:21255106 doi:10.1111/j.1365-2958.2010.07482.x

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OCA

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