4b5p
From Proteopedia
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{{STRUCTURE_4b5p| PDB=4b5p | SCENE= }} | {{STRUCTURE_4b5p| PDB=4b5p | SCENE= }} | ||
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===Crystal structure of human alpha tubulin acetyltransferase catalytic domain Q58A variant=== | ===Crystal structure of human alpha tubulin acetyltransferase catalytic domain Q58A variant=== | ||
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{{ABSTRACT_PUBMED_23071318}} | {{ABSTRACT_PUBMED_23071318}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/ATAT_HUMAN ATAT_HUMAN]] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development.<ref>PMID:20829795</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[4b5p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B5P OCA]. | [[4b5p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B5P OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023071318</ref><references group="xtra"/><references/> | ||
[[Category: Alpha-tubulin N-acetyltransferase]] | [[Category: Alpha-tubulin N-acetyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 03:59, 12 September 2013
Contents |
Crystal structure of human alpha tubulin acetyltransferase catalytic domain Q58A variant
Template:ABSTRACT PUBMED 23071318
Function
[ATAT_HUMAN] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development.[1]
About this Structure
4b5p is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Taschner M, Vetter M, Lorentzen E. Atomic resolution structure of human alpha-tubulin acetyltransferase bound to acetyl-CoA. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19649-54. doi:, 10.1073/pnas.1209343109. Epub 2012 Oct 15. PMID:23071318 doi:10.1073/pnas.1209343109
- ↑ Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J. MEC-17 is an alpha-tubulin acetyltransferase. Nature. 2010 Sep 9;467(7312):218-22. doi: 10.1038/nature09324. PMID:20829795 doi:10.1038/nature09324
