4k2p
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
{{STRUCTURE_4k2p| PDB=4k2p | SCENE= }} | {{STRUCTURE_4k2p| PDB=4k2p | SCENE= }} | ||
===The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain=== | ===The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain=== | ||
| + | {{ABSTRACT_PUBMED_23832200}} | ||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4k2p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K2P OCA]. | [[4k2p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K2P OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023832200</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fuentes, E J.]] | [[Category: Fuentes, E J.]] | ||
Revision as of 04:12, 12 September 2013
Contents |
The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain
Template:ABSTRACT PUBMED 23832200
Function
[TIAM1_HUMAN] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
About this Structure
4k2p is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Joshi M, Gakhar L, Fuentes EJ. High-resolution structure of the Tiam1 PHn-CC-Ex domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jul;69(Pt 7):744-52. doi: , 10.1107/S1744309113014206. Epub 2013 Jun 27. PMID:23832200 doi:10.1107/S1744309113014206
