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2lo9
From Proteopedia
(Difference between revisions)
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| - | [[Image:2lo9.jpg|left|200px]] | ||
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{{STRUCTURE_2lo9| PDB=2lo9 | SCENE= }} | {{STRUCTURE_2lo9| PDB=2lo9 | SCENE= }} | ||
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===NMR solution structure of Mu-contoxin BuIIIB=== | ===NMR solution structure of Mu-contoxin BuIIIB=== | ||
| + | {{ABSTRACT_PUBMED_23557677}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CM3B_CONBU CM3B_CONBU]] Mu-conotoxins block voltage-gated sodium channels. Extremely potent inhibitor of Nav1.4/SCN4A. The inhibition is very slowly reversible. | ||
==About this Structure== | ==About this Structure== | ||
[[2lo9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO9 OCA]. | [[2lo9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO9 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023557677</ref><references group="xtra"/><references/> | ||
[[Category: Kuang, Z.]] | [[Category: Kuang, Z.]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 04:21, 12 September 2013
Contents |
NMR solution structure of Mu-contoxin BuIIIB
Template:ABSTRACT PUBMED 23557677
Function
[CM3B_CONBU] Mu-conotoxins block voltage-gated sodium channels. Extremely potent inhibitor of Nav1.4/SCN4A. The inhibition is very slowly reversible.
About this Structure
2lo9 is a 1 chain structure. Full experimental information is available from OCA.
Reference
- Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G, Norton RS. Mammalian Neuronal Sodium Channel Blocker mu-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency. ACS Chem Biol. 2013 Apr 16. PMID:23557677 doi:10.1021/cb300674x
