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4lla

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4lla| PDB=4lla | SCENE= }}
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===Crystal structure of D3D4 domain of the LILRB2 molecule===
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{{ABSTRACT_PUBMED_23955630}}
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The entry 4lla is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/LIRB2_HUMAN LIRB2_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9548455</ref> <ref>PMID:9842885</ref> <ref>PMID:11875462</ref> <ref>PMID:12853576</ref>
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Authors: Nam, G., Shi, Y., Ryu, M., Wang, Q., Song, H., Liu, J., Yan, J., Qi, J., Gao, G.F.
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==About this Structure==
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[[4lla]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLA OCA].
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Description: Crystal structure of D3D4 domain of the LILRB2 molecule
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==Reference==
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<ref group="xtra">PMID:023955630</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Gao, G F.]]
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[[Category: Liu, J.]]
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[[Category: Nam, G.]]
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[[Category: Qi, J.]]
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[[Category: Ryu, M.]]
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[[Category: Shi, Y.]]
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[[Category: Song, H.]]
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[[Category: Wang, Q.]]
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[[Category: Yan, J.]]
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[[Category: Ig-like domain]]
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[[Category: Immune system]]
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[[Category: Immune-modulatory molecule]]

Revision as of 05:17, 12 September 2013

Template:STRUCTURE 4lla

Contents

Crystal structure of D3D4 domain of the LILRB2 molecule

Template:ABSTRACT PUBMED 23955630

Function

[LIRB2_HUMAN] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.[1] [2] [3] [4]

About this Structure

4lla is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Nam G, Shi Y, Ryu M, Wang Q, Song H, Liu J, Yan J, Qi J, Gao GF. Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding. Protein Cell. 2013 Aug 17. PMID:23955630 doi:10.1007/s13238-013-3908-x
  1. ↑ Borges L, Hsu ML, Fanger N, Kubin M, Cosman D. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J Immunol. 1997 Dec 1;159(11):5192-6. PMID:9548455
  2. ↑ Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur J Immunol. 1998 Nov;28(11):3423-34. PMID:9842885
  3. ↑ Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, Lederman S, Colonna M, Cortesini R, Dalla-Favera R, Suciu-Foca N. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol. 2002 Mar;3(3):237-43. Epub 2002 Jan 28. PMID:11875462 doi:10.1038/ni760
  4. ↑ Shiroishi M, Tsumoto K, Amano K, Shirakihara Y, Colonna M, Braud VM, Allan DS, Makadzange A, Rowland-Jones S, Willcox B, Jones EY, van der Merwe PA, Kumagai I, Maenaka K. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8856-61. Epub 2003 Jul 9. PMID:12853576 doi:10.1073/pnas.1431057100

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