4je5

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'''Unreleased structure'''
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{{STRUCTURE_4je5| PDB=4je5 | SCENE= }}
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===Crystal structure of the aromatic aminotransferase Aro8, a putative alpha-aminoadipate aminotransferase in Saccharomyces cerevisiae===
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{{ABSTRACT_PUBMED_23893908}}
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The entry 4je5 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ARO8_YEAST ARO8_YEAST]] General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways. Responsible for phenylalanine and tyrosine biosynthesis. Active with glutamate, phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate, 2-oxoglutarate and pyruvate as amino acceptors. Also active with methionine, alpha-aminoadipate and leucine as amino donors when phenylpyruvate is the amino acceptor and in the reverse reactions with the corresponding oxo acids and phenylalanine as amino donor. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors. Catalyzes the formation of alpha-aminoadipate from alpha-ketoadipate in the lysine biosyntheic pathway.<ref>PMID:9491083</ref> <ref>PMID:6763508</ref> <ref>PMID:9491082</ref> <ref>PMID:18625006</ref> <ref>PMID:21982920</ref>
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Authors: Bulfer, S.L., Brunzelle, J.S., Trievel, R.C.
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==About this Structure==
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[[4je5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE5 OCA].
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Description: Crystal structure of the aromatic aminotransferase Aro8, a putative alpha-aminoadipate aminotransferase in Saccharomyces cerevisiae
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==Reference==
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<ref group="xtra">PMID:023893908</ref><references group="xtra"/><references/>
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Brunzelle, J S.]]
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[[Category: Bulfer, S L.]]
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[[Category: Trievel, R C.]]
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[[Category: Alpha-aminoadipate aminotransferase]]
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[[Category: Aromatic aminotransferase]]
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[[Category: Multifunctional enzyme]]
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[[Category: Plp-dependent]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Transferase]]

Revision as of 05:19, 12 September 2013

Template:STRUCTURE 4je5

Contents

Crystal structure of the aromatic aminotransferase Aro8, a putative alpha-aminoadipate aminotransferase in Saccharomyces cerevisiae

Template:ABSTRACT PUBMED 23893908

Function

[ARO8_YEAST] General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways. Responsible for phenylalanine and tyrosine biosynthesis. Active with glutamate, phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate, 2-oxoglutarate and pyruvate as amino acceptors. Also active with methionine, alpha-aminoadipate and leucine as amino donors when phenylpyruvate is the amino acceptor and in the reverse reactions with the corresponding oxo acids and phenylalanine as amino donor. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors. Catalyzes the formation of alpha-aminoadipate from alpha-ketoadipate in the lysine biosyntheic pathway.[1] [2] [3] [4] [5]

About this Structure

4je5 is a 4 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  • Bulfer SL, Brunzelle JS, Trievel RC. Crystal structure of Saccharomyces cerevisiae Aro8, a putative alpha-aminoadipate aminotransferase. Protein Sci. 2013 Jul 24. doi: 10.1002/pro.2315. PMID:23893908 doi:10.1002/pro.2315
  1. ↑ Iraqui I, Vissers S, Cartiaux M, Urrestarazu A. Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily. Mol Gen Genet. 1998 Jan;257(2):238-48. PMID:9491083
  2. ↑ Kradolfer P, Niederberger P, Hutter R. Tryptophan degradation in Saccharomyces cerevisiae: characterization of two aromatic aminotransferases. Arch Microbiol. 1982 Dec 11;133(3):242-8. PMID:6763508
  3. ↑ Urrestarazu A, Vissers S, Iraqui I, Grenson M. Phenylalanine- and tyrosine-auxotrophic mutants of Saccharomyces cerevisiae impaired in transamination. Mol Gen Genet. 1998 Jan;257(2):230-7. PMID:9491082
  4. ↑ Pirkov I, Norbeck J, Gustafsson L, Albers E. A complete inventory of all enzymes in the eukaryotic methionine salvage pathway. FEBS J. 2008 Aug;275(16):4111-20. doi: 10.1111/j.1742-4658.2008.06552.x. Epub, 2008 Jul 10. PMID:18625006 doi:10.1111/j.1742-4658.2008.06552.x
  5. ↑ Karsten WE, Reyes ZL, Bobyk KD, Cook PF, Chooback L. Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae. Arch Biochem Biophys. 2011 Dec 1;516(1):67-74. doi: 10.1016/j.abb.2011.09.008., Epub 2011 Sep 29. PMID:21982920 doi:10.1016/j.abb.2011.09.008

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