4bw2

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m (Protected "4bw2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bw2| PDB=4bw2 | SCENE= }}
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===The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand===
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{{ABSTRACT_PUBMED_24000170}}
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The entry 4bw2 is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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Authors: Chung, C., Mirguet, O., Lamotte, Y., Bamborough, P., Delannee, D., Bouillot, A., Gellibert, F., Krysa, G., Lewis, A., Witherington, J., Huet, P., Dudit, Y., Trottet, L., Nicodeme, E.
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==Function==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Description: The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand
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==About this Structure==
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[[4bw2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW2 OCA].
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==Reference==
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<ref group="xtra">PMID:024000170</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Bamborough, P.]]
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[[Category: Bouillot, A.]]
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[[Category: Chung, C.]]
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[[Category: Delannee, D.]]
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[[Category: Dudit, Y.]]
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[[Category: Gellibert, F.]]
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[[Category: Huet, P.]]
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[[Category: Krysa, G.]]
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[[Category: Lamotte, Y.]]
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[[Category: Lewis, A.]]
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[[Category: Mirguet, O.]]
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[[Category: Nicodeme, E.]]
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[[Category: Trottet, L.]]
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[[Category: Witherington, J.]]
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[[Category: Antagonist]]
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[[Category: Epigenetic reader]]
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[[Category: Histone]]
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[[Category: Inhibitor]]
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[[Category: Transcription]]

Revision as of 05:19, 12 September 2013

Template:STRUCTURE 4bw2

Contents

The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand

Template:ABSTRACT PUBMED 24000170

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4bw2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mirguet O, Lamotte Y, Chung CW, Bamborough P, Delannee D, Bouillot A, Gellibert F, Krysa G, Lewis A, Witherington J, Huet P, Dudit Y, Trottet L, Nicodeme E. Naphthyridines as Novel BET Family Bromodomain Inhibitors. ChemMedChem. 2013 Sep 2. doi: 10.1002/cmdc.201300259. PMID:24000170 doi:10.1002/cmdc.201300259
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

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