4ldc

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'''Unreleased structure'''
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{{STRUCTURE_4ldc| PDB=4ldc | SCENE= }}
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===Crystal Structure of DOC2B C2B domain===
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{{ABSTRACT_PUBMED_23994332}}
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The entry 4ldc is ON HOLD until Sep 05 2014
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==Function==
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[[http://www.uniprot.org/uniprot/DOC2B_RAT DOC2B_RAT]] Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.<ref>PMID:18596155</ref> <ref>PMID:20150444</ref>
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Authors: Giladi, M., Almagor, L., Hirsch, J.A.
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==About this Structure==
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[[4ldc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDC OCA].
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Description: Crystal Structure of DOC2B C2B domain
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==Reference==
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<ref group="xtra">PMID:023994332</ref><references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Almagor, L.]]
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[[Category: Giladi, M.]]
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[[Category: Hirsch, J A.]]
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[[Category: C2]]
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[[Category: Calcium binding domain]]
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[[Category: Metal binding protein]]

Revision as of 05:22, 12 September 2013

Template:STRUCTURE 4ldc

Contents

Crystal Structure of DOC2B C2B domain

Template:ABSTRACT PUBMED 23994332

Function

[DOC2B_RAT] Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.[1] [2]

About this Structure

4ldc is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Giladi M, Michaely L, Almagor L, Bar-On D, Buki T, Ashery U, Khananshvili D, Hirsch JA. The C2B Domain Is the Primary Ca Sensor in DOC2B: A Structural and Functional Analysis. J Mol Biol. 2013 Aug 28. pii: S0022-2836(13)00537-8. doi:, 10.1016/j.jmb.2013.08.017. PMID:23994332 doi:10.1016/j.jmb.2013.08.017
  1. ↑ Friedrich R, Groffen AJ, Connell E, van Weering JR, Gutman O, Henis YI, Davletov B, Ashery U. DOC2B acts as a calcium switch and enhances vesicle fusion. J Neurosci. 2008 Jul 2;28(27):6794-806. doi: 10.1523/JNEUROSCI.0538-08.2008. PMID:18596155 doi:10.1523/JNEUROSCI.0538-08.2008
  2. ↑ Groffen AJ, Martens S, Diez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, McMahon HT, Verhage M. Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science. 2010 Mar 26;327(5973):1614-8. doi: 10.1126/science.1183765. Epub 2010, Feb 11. PMID:20150444 doi:10.1126/science.1183765

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