4ll9

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m (Protected "4ll9" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4ll9| PDB=4ll9 | SCENE= }}
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===Crystal structure of D3D4 domain of the LILRB1 molecule===
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{{ABSTRACT_PUBMED_23955630}}
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The entry 4ll9 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>
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Authors: Nam, G., Shi, Y., Ryu, M., Wang, Q., Song, H., Liu, J., Yan, J., Qi, J., Gao, G.F.
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==About this Structure==
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[[4ll9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LL9 OCA].
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Description: Crystal structure of D3D4 domain of the LILRB1 molecule
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==Reference==
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<ref group="xtra">PMID:023955630</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Gao, G F.]]
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[[Category: Liu, J.]]
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[[Category: Nam, G.]]
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[[Category: Qi, J.]]
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[[Category: Ryu, M.]]
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[[Category: Shi, Y.]]
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[[Category: Song, H.]]
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[[Category: Wang, Q.]]
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[[Category: Yan, J.]]
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[[Category: Ig-like domain]]
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[[Category: Immune system]]
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[[Category: Immune-modulatory molecule]]

Revision as of 05:26, 12 September 2013

Template:STRUCTURE 4ll9

Contents

Crystal structure of D3D4 domain of the LILRB1 molecule

Template:ABSTRACT PUBMED 23955630

Function

[LIRB1_HUMAN] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.[1] [2] [3]

About this Structure

4ll9 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Nam G, Shi Y, Ryu M, Wang Q, Song H, Liu J, Yan J, Qi J, Gao GF. Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding. Protein Cell. 2013 Aug 17. PMID:23955630 doi:10.1007/s13238-013-3908-x
  1. ↑ Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 1997 Aug;7(2):273-82. PMID:9285411
  2. ↑ Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur J Immunol. 1998 Nov;28(11):3423-34. PMID:9842885
  3. ↑ Bellon T, Kitzig F, Sayos J, Lopez-Botet M. Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. J Immunol. 2002 Apr 1;168(7):3351-9. PMID:11907092

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