This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4ll9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4ll9" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4ll9| PDB=4ll9 | SCENE= }}
 +
===Crystal structure of D3D4 domain of the LILRB1 molecule===
 +
{{ABSTRACT_PUBMED_23955630}}
-
The entry 4ll9 is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>
-
Authors: Nam, G., Shi, Y., Ryu, M., Wang, Q., Song, H., Liu, J., Yan, J., Qi, J., Gao, G.F.
+
==About this Structure==
 +
[[4ll9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LL9 OCA].
-
Description: Crystal structure of D3D4 domain of the LILRB1 molecule
+
==Reference==
 +
<ref group="xtra">PMID:023955630</ref><references group="xtra"/><references/>
 +
[[Category: Homo sapiens]]
 +
[[Category: Gao, G F.]]
 +
[[Category: Liu, J.]]
 +
[[Category: Nam, G.]]
 +
[[Category: Qi, J.]]
 +
[[Category: Ryu, M.]]
 +
[[Category: Shi, Y.]]
 +
[[Category: Song, H.]]
 +
[[Category: Wang, Q.]]
 +
[[Category: Yan, J.]]
 +
[[Category: Ig-like domain]]
 +
[[Category: Immune system]]
 +
[[Category: Immune-modulatory molecule]]

Revision as of 05:26, 12 September 2013

Template:STRUCTURE 4ll9

Contents

Crystal structure of D3D4 domain of the LILRB1 molecule

Template:ABSTRACT PUBMED 23955630

Function

[LIRB1_HUMAN] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.[1] [2] [3]

About this Structure

4ll9 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Nam G, Shi Y, Ryu M, Wang Q, Song H, Liu J, Yan J, Qi J, Gao GF. Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding. Protein Cell. 2013 Aug 17. PMID:23955630 doi:10.1007/s13238-013-3908-x
  1. ↑ Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 1997 Aug;7(2):273-82. PMID:9285411
  2. ↑ Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur J Immunol. 1998 Nov;28(11):3423-34. PMID:9842885
  3. ↑ Bellon T, Kitzig F, Sayos J, Lopez-Botet M. Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. J Immunol. 2002 Apr 1;168(7):3351-9. PMID:11907092

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ll9"
Personal tools