3rzc
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[Image:3rzc.png|left|200px]] | ||
| - | |||
{{STRUCTURE_3rzc| PDB=3rzc | SCENE= }} | {{STRUCTURE_3rzc| PDB=3rzc | SCENE= }} | ||
| - | |||
===Structure of the self-antigen iGb3 bound to mouse CD1d and in complex with the iNKT TCR=== | ===Structure of the self-antigen iGb3 bound to mouse CD1d and in complex with the iNKT TCR=== | ||
| + | {{ABSTRACT_PUBMED_21810611}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3rzc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZC OCA]. | + | [[3rzc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZC OCA]. |
==See Also== | ==See Also== | ||
*[[Beta-2 microglobulin|Beta-2 microglobulin]] | *[[Beta-2 microglobulin|Beta-2 microglobulin]] | ||
| + | *[[CD1|CD1]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021810611</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021810611</ref><references group="xtra"/><references/> |
| + | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Girardi, E.]] | [[Category: Girardi, E.]] | ||
Revision as of 02:38, 20 September 2013
Contents |
Structure of the self-antigen iGb3 bound to mouse CD1d and in complex with the iNKT TCR
Template:ABSTRACT PUBMED 21810611
Function
[CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.[1] [2] [3] [B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
About this Structure
3rzc is a 4 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
See Also
Reference
- Yu ED, Girardi E, Wang J, Zajonc DM. Cutting Edge: Structural Basis for the Recognition of {beta}-Linked Glycolipid Antigens by Invariant NKT Cells. J Immunol. 2011 Sep 1;187(5):2079-83. Epub 2011 Aug 1. PMID:21810611 doi:10.4049/jimmunol.1101636
- ↑ Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec;15(6):897-908. PMID:11754812
- ↑ Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439 doi:10.1084/jem.20051625
- ↑ Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091 doi:10.1038/ni1224
