2z5h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
{{STRUCTURE_2z5h| PDB=2z5h | SCENE= }}
{{STRUCTURE_2z5h| PDB=2z5h | SCENE= }}
===Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT===
===Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT===
-
{{ABSTRACT_PUBMED_018483193}}
+
{{ABSTRACT_PUBMED_18483193}}
 +
 
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'. [[http://www.uniprot.org/uniprot/TNNT3_CHICK TNNT3_CHICK]] Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. [[http://www.uniprot.org/uniprot/TPM1_RABIT TPM1_RABIT]] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
==About this Structure==
==About this Structure==
Line 11: Line 14:
==Reference==
==Reference==
-
<ref group="xtra">PMID:018483193</ref><references group="xtra"/>
+
<ref group="xtra">PMID:018483193</ref><references group="xtra"/><references/>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]

Revision as of 02:44, 20 September 2013

Template:STRUCTURE 2z5h

Contents

Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT

Template:ABSTRACT PUBMED 18483193

Function

[GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'. [TNNT3_CHICK] Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. [TPM1_RABIT] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

About this Structure

2z5h is a 10 chain structure with sequence from Gallus gallus, Oryctolagus cuniculus and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

See Also

Reference

  • Murakami K, Stewart M, Nozawa K, Tomii K, Kudou N, Igarashi N, Shirakihara Y, Wakatsuki S, Yasunaga T, Wakabayashi T. Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7200-5. Epub 2008 May 15. PMID:18483193 doi:10.1073/pnas.0801950105

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2z5h"
Personal tools