3l9k

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[[Image:3l9k.png|left|200px]]
 
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{{STRUCTURE_3l9k| PDB=3l9k | SCENE= }}
{{STRUCTURE_3l9k| PDB=3l9k | SCENE= }}
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===Insights into dynein assembly from a dynein intermediate chain-light chain roadblock structure===
===Insights into dynein assembly from a dynein intermediate chain-light chain roadblock structure===
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{{ABSTRACT_PUBMED_020472935}}
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==Function==
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[[http://www.uniprot.org/uniprot/DYIN_DROME DYIN_DROME]] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).<ref>PMID:11071907</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:020472935</ref><references group="xtra"/>
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<ref group="xtra">PMID:020472935</ref><references group="xtra"/><references/>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Barbar, E.]]
[[Category: Barbar, E.]]

Revision as of 03:08, 20 September 2013

Template:STRUCTURE 3l9k

Contents

Insights into dynein assembly from a dynein intermediate chain-light chain roadblock structure

Function

[DYIN_DROME] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).[1]

About this Structure

3l9k is a 8 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

See Also

Reference

  • Hall J, Song Y, Karplus PA, Barbar E. The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly. J Biol Chem. 2010 Jul 16;285(29):22566-75. Epub 2010 May 15. PMID:20472935 doi:10.1074/jbc.M110.103861
  1. ↑ Boylan K, Serr M, Hays T. A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex. Mol Biol Cell. 2000 Nov;11(11):3791-803. PMID:11071907

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OCA

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