2o8h
From Proteopedia
(New page: 200px<br /><applet load="2o8h" size="350" color="white" frame="true" align="right" spinBox="true" caption="2o8h, resolution 1.800Å" /> '''Crystal structure o...) |
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==Overview== | ==Overview== | ||
| - | A papaverine based pharmacophore model for PDE10A inhibition was generated | + | A papaverine based pharmacophore model for PDE10A inhibition was generated via SBDD and used to design a library of 4-amino-6,7-dimethoxyquinazolines. From this library emerged an aryl ether pyrrolidyl 6,7-dimethoxyquinazoline series that became the focal point for additional modeling, X-ray, and synthetic efforts toward increasing PDE10A inhibitory potency and selectivity versus PDE3A/B. These efforts culminated in the discovery of 29, a potent and selective brain penetrable inhibitor of PDE10A. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Marr, E | + | [[Category: Marr, E S.]] |
[[Category: Pandit, J.]] | [[Category: Pandit, J.]] | ||
[[Category: 227]] | [[Category: 227]] | ||
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[[Category: phosphodiesterase 10a; zn-binding site]] | [[Category: phosphodiesterase 10a; zn-binding site]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:15:41 2008'' |
Revision as of 16:15, 21 February 2008
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Crystal structure of the catalytic domain of rat phosphodiesterase 10A
Overview
A papaverine based pharmacophore model for PDE10A inhibition was generated via SBDD and used to design a library of 4-amino-6,7-dimethoxyquinazolines. From this library emerged an aryl ether pyrrolidyl 6,7-dimethoxyquinazoline series that became the focal point for additional modeling, X-ray, and synthetic efforts toward increasing PDE10A inhibitory potency and selectivity versus PDE3A/B. These efforts culminated in the discovery of 29, a potent and selective brain penetrable inhibitor of PDE10A.
About this Structure
2O8H is a Single protein structure of sequence from Rattus norvegicus with , and as ligands. Active as 3',5'-cyclic-nucleotide phosphodiesterase, with EC number 3.1.4.17 Full crystallographic information is available from OCA.
Reference
Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors., Chappie TA, Humphrey JM, Allen MP, Estep KG, Fox CB, Lebel LA, Liras S, Marr ES, Menniti FS, Pandit J, Schmidt CJ, Tu M, Williams RD, Yang FV, J Med Chem. 2007 Jan 25;50(2):182-5. PMID:17228859
Page seeded by OCA on Thu Feb 21 18:15:41 2008
