4bnt

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m (Protected "4bnt" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bnt| PDB=4bnt | SCENE= }}
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===Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2-(trifluoromethyl)-1H- benzimidazole at 2.3A resolution===
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{{ABSTRACT_PUBMED_24015914}}
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The entry 4bnt is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/FABG_PSEAE FABG_PSEAE]] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity).
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Authors: CUKIER, C.D., SCHNELL, R., LINDQVIST, Y., SCHNEIDER, G.
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==About this Structure==
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[[4bnt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BNT OCA].
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Description: Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2-(trifluoromethyl)-1H-benzimidazole at 2.3A resolution
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==Reference==
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<ref group="xtra">PMID:024015914</ref><references group="xtra"/><references/>
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[[Category: Pseudomonas aeruginosa pao1]]
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[[Category: Cukier, C D.]]
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[[Category: Lindqvist, Y.]]
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[[Category: Schneider, G.]]
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[[Category: Schnell, R.]]
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[[Category: Fatty acid biosynthesis]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]

Revision as of 04:10, 20 September 2013

Template:STRUCTURE 4bnt

Contents

Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2-(trifluoromethyl)-1H- benzimidazole at 2.3A resolution

Template:ABSTRACT PUBMED 24015914

Function

[FABG_PSEAE] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis (By similarity).

About this Structure

4bnt is a 4 chain structure with sequence from Pseudomonas aeruginosa pao1. Full crystallographic information is available from OCA.

Reference

  • Cukier CD, Hope AG, Elamin AA, Moynie L, Schnell R, Schach S, Kneuper H, Singh M, Naismith JH, Lindqvist Y, Gray DW, Schneider G. Discovery of an allosteric inhibitor binding site in 3-oxo-acyl-ACP reductase from Pseudomonas aeruginosa. ACS Chem Biol. 2013 Sep 9. PMID:24015914 doi:10.1021/cb4005063

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OCA

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