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4jva

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4jva| PDB=4jva | SCENE= }}
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===Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog===
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{{ABSTRACT_PUBMED_23978166}}
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The entry 4jva is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/KAP3_RAT KAP3_RAT]] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
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Authors: Brown, S.H.J., Cheng, C.Y., Saldanha, A.S., Wu, J., Cottam, H., Sankaran, B., Taylor, S.S.
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==About this Structure==
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[[4jva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVA OCA].
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Description: Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog
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==Reference==
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<ref group="xtra">PMID:023978166</ref><references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Brown, S H.J.]]
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[[Category: Cheng, C Y.]]
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[[Category: Cottam, H.]]
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[[Category: Saldanha, A S.]]
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[[Category: Sankaran, B.]]
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[[Category: Taylor, S S.]]
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[[Category: Wu, J.]]
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[[Category: Camp-dependent protein kinase]]
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[[Category: Cyclic nucleotide analog]]
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[[Category: Fluorescence anisotropy]]
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[[Category: Isoform selectivity]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 04:11, 20 September 2013

Template:STRUCTURE 4jva

Contents

Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog

Template:ABSTRACT PUBMED 23978166

Function

[KAP3_RAT] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

About this Structure

4jva is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor SS. Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs. ACS Chem Biol. 2013 Sep 10. PMID:23978166 doi:10.1021/cb400247t

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OCA

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