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4hwp

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'''Unreleased structure'''
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{{STRUCTURE_4hwp| PDB=4hwp | SCENE= }}
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===Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor===
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{{ABSTRACT_PUBMED_23362938}}
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The entry 4hwp is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SYT_ECOLI SYT_ECOLI]] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184]
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Authors: Hilgers, M.T.
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==About this Structure==
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[[4hwp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWP OCA].
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Description: Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor
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==Reference==
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<ref group="xtra">PMID:023362938</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli k-12]]
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[[Category: Threonine--tRNA ligase]]
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[[Category: Hilgers, M T.]]
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[[Category: Aminoacyl-trna synthetase]]
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[[Category: Antibacterial]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Protein-inhibitor complex]]

Revision as of 04:13, 20 September 2013

Template:STRUCTURE 4hwp

Contents

Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor

Template:ABSTRACT PUBMED 23362938

Function

[SYT_ECOLI] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184]

About this Structure

4hwp is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Teng M, Hilgers MT, Cunningham ML, Borchardt A, Locke JB, Abraham S, Haley G, Kwan BP, Hall C, Hough GW, Shaw KJ, Finn J. Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J Med Chem. 2013 Feb 28;56(4):1748-60. doi: 10.1021/jm301756m. Epub 2013 Feb 12. PMID:23362938 doi:10.1021/jm301756m

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OCA

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