4hwp

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-	'''Unreleased structure'''	+	{{STRUCTURE_4hwp| PDB=4hwp | SCENE= }}
		+	===Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor===
		+	{{ABSTRACT_PUBMED_23362938}}
-	The entry 4hwp is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SYT_ECOLI SYT_ECOLI]] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184]
-	Authors: Hilgers, M.T.	+	==About this Structure==
		+	[[4hwp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWP OCA].
-	Description: Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor	+	==Reference==
		+	<ref group="xtra">PMID:023362938</ref><references group="xtra"/><references/>
		+	[[Category: Escherichia coli k-12]]
		+	[[Category: Threonine--tRNA ligase]]
		+	[[Category: Hilgers, M T.]]
		+	[[Category: Aminoacyl-trna synthetase]]
		+	[[Category: Antibacterial]]
		+	[[Category: Ligase-ligase inhibitor complex]]
		+	[[Category: Protein-inhibitor complex]]

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Revision as of 04:13, 20 September 2013

Template:STRUCTURE 4hwp

Contents 1 Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor 2 Function 3 About this Structure 4 Reference

Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor

Template:ABSTRACT PUBMED 23362938

Function

[SYT_ECOLI] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184]

About this Structure

4hwp is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

• Teng M, Hilgers MT, Cunningham ML, Borchardt A, Locke JB, Abraham S, Haley G, Kwan BP, Hall C, Hough GW, Shaw KJ, Finn J. Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J Med Chem. 2013 Feb 28;56(4):1748-60. doi: 10.1021/jm301756m. Epub 2013 Feb 12. PMID:23362938 doi:10.1021/jm301756m