4klb

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'''Unreleased structure'''
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{{STRUCTURE_4klb| PDB=4klb | SCENE= }}
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===Crystal Structure of Cruzain in complex with the non-covalent inhibitor Nequimed176===
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{{ABSTRACT_PUBMED_23991231}}
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The entry 4klb is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
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Authors: Fernandes, W.B., Montanari, C.A., Mckerrow, J.H.
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==About this Structure==
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[[4klb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLB OCA].
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Description: Crystal Structure of Cruzain in complex with the non-covalent inhibitor Nequimed176
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==Reference==
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<ref group="xtra">PMID:023991231</ref><references group="xtra"/><references/>
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[[Category: Cruzipain]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Fernandes, W B.]]
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[[Category: Mckerrow, J H.]]
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[[Category: Montanari, C A.]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protease]]
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[[Category: Thiol protease]]

Revision as of 04:14, 20 September 2013

Template:STRUCTURE 4klb

Contents

Crystal Structure of Cruzain in complex with the non-covalent inhibitor Nequimed176

Template:ABSTRACT PUBMED 23991231

Function

[CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.

About this Structure

4klb is a 5 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference

  • Wiggers HJ, Rocha JR, Fernandes WB, Sesti-Costa R, Carneiro ZA, Cheleski J, da Silva AB, Juliano L, Cezari MH, Silva JS, McKerrow JH, Montanari CA. Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay. PLoS Negl Trop Dis. 2013 Aug 22;7(8):e2370. doi: 10.1371/journal.pntd.0002370. PMID:23991231 doi:10.1371/journal.pntd.0002370

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