3iga

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[[Image:3iga.png|left|200px]]
 
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{{STRUCTURE_3iga| PDB=3iga | SCENE= }}
{{STRUCTURE_3iga| PDB=3iga | SCENE= }}
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===Potassium Channel KcsA-Fab complex in Li+ and K+===
===Potassium Channel KcsA-Fab complex in Li+ and K+===
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{{ABSTRACT_PUBMED_19946269}}
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{{ABSTRACT_PUBMED_19946269}}
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==Function==
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[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019946269</ref><references group="xtra"/>
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<ref group="xtra">PMID:019946269</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Streptomyces lividans]]
[[Category: Streptomyces lividans]]

Revision as of 06:41, 29 September 2013

Template:STRUCTURE 3iga

Contents

Potassium Channel KcsA-Fab complex in Li+ and K+

Template:ABSTRACT PUBMED 19946269

Function

[KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).[1]

About this Structure

3iga is a 3 chain structure with sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

See Also

Reference

  • Thompson AN, Kim I, Panosian TD, Iverson TM, Allen TW, Nimigean CM. Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nat Struct Mol Biol. 2009 Dec;16(12):1317-24. Epub 2009 Nov 29. PMID:19946269 doi:10.1038/nsmb.1703
  1. ↑ Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Muller D, Betzler M, Steinkamp T, Wagner R. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 1995 Nov 1;14(21):5170-8. PMID:7489706

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OCA

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