3b9k
From Proteopedia
(Difference between revisions)
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| - | [[Image:3b9k.png|left|200px]] | ||
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{{STRUCTURE_3b9k| PDB=3b9k | SCENE= }} | {{STRUCTURE_3b9k| PDB=3b9k | SCENE= }} | ||
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===Crystal structure of CD8alpha-beta in complex with YTS 156.7 FAB=== | ===Crystal structure of CD8alpha-beta in complex with YTS 156.7 FAB=== | ||
| + | {{ABSTRACT_PUBMED_18929574}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CD8B_MOUSE CD8B_MOUSE]] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. [[http://www.uniprot.org/uniprot/CD8A_MOUSE CD8A_MOUSE]] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. | ||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
| + | *[[CD8|CD8]] | ||
*[[Monoclonal Antibody|Monoclonal Antibody]] | *[[Monoclonal Antibody|Monoclonal Antibody]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:018929574</ref><references group="xtra"/> | + | <ref group="xtra">PMID:018929574</ref><references group="xtra"/><references/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Rattus rattus]] | [[Category: Rattus rattus]] | ||
Revision as of 06:49, 29 September 2013
Contents |
Crystal structure of CD8alpha-beta in complex with YTS 156.7 FAB
Template:ABSTRACT PUBMED 18929574
Function
[CD8B_MOUSE] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. [CD8A_MOUSE] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
About this Structure
3b9k is a 8 chain structure with sequence from Mus musculus and Rattus rattus. Full crystallographic information is available from OCA.
See Also
Reference
- Shore DA, Issafras H, Landais E, Teyton L, Wilson IA. The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I. J Mol Biol. 2008 Dec 31;384(5):1190-202. Epub 2008 Oct 7. PMID:18929574 doi:10.1016/j.jmb.2008.09.069
