3u6e

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[[Image:3u6e.png|left|200px]]
 
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{{STRUCTURE_3u6e| PDB=3u6e | SCENE= }}
{{STRUCTURE_3u6e| PDB=3u6e | SCENE= }}
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===MutM set 1 TpGo===
===MutM set 1 TpGo===
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{{ABSTRACT_PUBMED_22465958}}
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{{ABSTRACT_PUBMED_22465958}}
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==Function==
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[[http://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:022465958</ref><references group="xtra"/>
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<ref group="xtra">PMID:022465958</ref><references group="xtra"/><references/>
[[Category: DNA-formamidopyrimidine glycosylase]]
[[Category: DNA-formamidopyrimidine glycosylase]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]

Revision as of 06:58, 29 September 2013

Template:STRUCTURE 3u6e

Contents

MutM set 1 TpGo

Template:ABSTRACT PUBMED 22465958

Function

[P84131_GEOSE] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]

About this Structure

3u6e is a 3 chain structure with sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

  • Sung RJ, Zhang M, Qi Y, Verdine GL. SEQUENCE-DEPENDENT STRUCTURAL VARIATION IN DNA UNDERGOING INTRAHELICAL INSPECTION BY MUTM. J Biol Chem. 2012 Mar 30. PMID:22465958 doi:10.1074/jbc.M111.313635

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OCA

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