This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3h15

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3h15" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:3h15.png|left|200px]]
 
- 
{{STRUCTURE_3h15| PDB=3h15 | SCENE= }}
{{STRUCTURE_3h15| PDB=3h15 | SCENE= }}
- 
===Crystal structure of replication initiation factor MCM10-ID bound to ssDNA===
===Crystal structure of replication initiation factor MCM10-ID bound to ssDNA===
 +
{{ABSTRACT_PUBMED_19608746}}
-
{{ABSTRACT_PUBMED_19608746}}
+
==Function==
 +
[[http://www.uniprot.org/uniprot/MCM10_XENLA MCM10_XENLA]] Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).<ref>PMID:11864598</ref>
==About this Structure==
==About this Structure==
Line 11: Line 10:
==Reference==
==Reference==
-
<ref group="xtra">PMID:019608746</ref><references group="xtra"/>
+
<ref group="xtra">PMID:019608746</ref><references group="xtra"/><references/>
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Eichman, B F.]]
[[Category: Eichman, B F.]]

Revision as of 06:58, 29 September 2013

Template:STRUCTURE 3h15

Contents

Crystal structure of replication initiation factor MCM10-ID bound to ssDNA

Template:ABSTRACT PUBMED 19608746

Function

[MCM10_XENLA] Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).[1]

About this Structure

3h15 is a 2 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

  • Warren EM, Huang H, Fanning E, Chazin WJ, Eichman BF. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem. 2009 Sep 4;284(36):24662-72. Epub 2009 Jul 16. PMID:19608746 doi:10.1074/jbc.M109.020438
  1. ↑ Wohlschlegel JA, Dhar SK, Prokhorova TA, Dutta A, Walter JC. Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol Cell. 2002 Feb;9(2):233-40. PMID:11864598

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3h15"
Personal tools