1w4x

From Proteopedia

Revision as of 14:20, 30 October 2007

PHENYLACETONE MONOOXYGENASE, A BAEYER-VILLIGER MONOOXYGENASE

Overview

Flavin-containing Baeyer-Villiger monooxygenases employ NADPH and, molecular oxygen to catalyze the insertion of an oxygen atom into a, carbon-carbon bond of a carbonylic substrate. These enzymes can, potentially be exploited in a variety of biocatalytic applications given, the wide use of Baeyer-Villiger reactions in synthetic organic chemistry., The catalytic activity of these enzymes involves the formation of two, crucial intermediates: a flavin peroxide generated by the reaction of the, reduced flavin with molecular oxygen and the "Criegee" intermediate, resulting from the attack of the flavin peroxide onto the substrate that, is being oxygenated. The crystal structure of phenylacetone monooxygenase, a Baeyer-Villiger monooxygenase from the thermophilic bacterium, Thermobifida fusca, ... [(full description)]

About this Structure

1W4X is a [Single protein] structure of sequence from [Thermobifida fusca] with SO4 and FAD as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Crystal structure of a Baeyer-Villiger monooxygenase., Malito E, Alfieri A, Fraaije MW, Mattevi A, Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13157-62. Epub 2004 Aug 24. PMID:15328411

Page seeded by OCA on Tue Oct 30 16:25:04 2007