3znl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_3znl| PDB=3znl | SCENE= }}
 +
===H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)===
-
The entry 3znl is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
-
Authors: Xiong, X., Tuzikov, A., Coombs, P., Martin, S.R., Walker, P.A., Gamblin, S.J., Bovin, N., Skehel, J.J.
+
==About this Structure==
 +
[[3znl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA].
-
Description: H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)
+
==Reference==
 +
<ref group="xtra">PMID:024036174</ref><references group="xtra"/><references/>
 +
[[Category: Influenza a virus]]
 +
[[Category: Bovin, N.]]
 +
[[Category: Coombs, P.]]
 +
[[Category: Gamblin, S J.]]
 +
[[Category: Martin, S R.]]
 +
[[Category: Skehel, J J.]]
 +
[[Category: Tuzikov, A.]]
 +
[[Category: Walker, P A.]]
 +
[[Category: Xiong, X.]]
 +
[[Category: Avian flu]]
 +
[[Category: Fucosylated sialoside]]
 +
[[Category: Fucosylation]]
 +
[[Category: Glycoprotein]]
 +
[[Category: Sialic acid]]
 +
[[Category: Sialyllactosamine]]
 +
[[Category: Sulfated sialoside]]
 +
[[Category: Sulfation]]
 +
[[Category: Viral protein]]
 +
[[Category: Virus receptor]]

Revision as of 08:11, 29 September 2013

Template:STRUCTURE 3znl

Contents

H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)

Function

[Q6DQ34_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

About this Structure

3znl is a 6 chain structure with sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

  • Xiong X, Tuzikov A, Coombs PJ, Martin S, Walker PA, Gamblin SJ, Bovin N, Skehel JJ. Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus. Virus Res. 2013 Sep 10. pii: S0168-1702(13)00286-4. doi:, 10.1016/j.virusres.2013.08.007. PMID:24036174 doi:10.1016/j.virusres.2013.08.007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3znl"
Personal tools